Essential role of ROS-mediated NFAT activation in TNF- induction by crystalline silica exposure
نویسندگان
چکیده
Qingdong Ke, Jingxia Li, Jin Ding, Min Ding, Liying Wang, Bingci Liu, Max Costa, and Chuanshu Huang Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, New York; Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia; and National Institute of Occupational Health and Poisons Control, Chinese Center for Diseases Control and Prevention, Beijing, China
منابع مشابه
Silica-induced chemokine expression in alveolar type II cells is mediated by TNF-a-induced oxidant stress
Barrett, Edward G., Carl Johnston, Günter Oberdörster, and Jacob N. Finkelstein. Silica-induced chemokine expression in alveolar type II cells is mediated by TNF-ainduced oxidant stress. Am. J. Physiol. 276 (Lung Cell. Mol. Physiol. 20): L979–L988, 1999.—We have shown previously that epithelial cells may contribute to the inflammatory response in the lung after exposure to crystalline silica th...
متن کاملSilica-induced chemokine expression in alveolar type II cells is mediated by TNF-α-induced oxidant stress.
We have shown previously that epithelial cells may contribute to the inflammatory response in the lung after exposure to crystalline silica through the production of and response to specific chemokines and cytokines. However, the exact cellular and molecular responses of epithelial cells to silica exposure remain unclear. We hypothesize that non-oxidant-mediated silica-cell interactions lead to...
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Acute activation of cells by tumor necrosis factor (TNF) has been well characterized, but little is known about later phases of TNF responses that are relevant for cells exposed to TNF for several days during inflammation. We found that prolonged exposure of human macrophages to TNF resulted in a wave of delayed but sustained activation of c-Jun and nuclear factor κB (NF-κB) proteins and of cal...
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Background: Silicosis as a most important work-related lung disease is generated of inhalation crystalline silica dust. Chemicals health risk assessment is essential to decide on priorities for control action and reduce the risk to an acceptable level. The aim of this study is evaluate workers' exposure to crystalline silica (quartz) and determine the qualitative and quantitative health risk le...
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